Over 2,600 peer-reviewed publications document HOCl’s safety and efficacy. Here are key studies that shaped our understanding:
Comprehensive review documenting HOCl’s exceptional antimicrobial efficacy and widely-studied safety profile, including studies against Cryptosporidium and other resistant pathogens.
Retrospective analysis of 1,249 venous leg ulcers in 897 patients treated with HOCl. All wounds achieved complete healing, with HOCl described as “perhaps the greatest advance in venous leg ulcer care.”
Comprehensive review documenting HOCl’s exceptional antimicrobial efficacy and widely-studied safety profile, including studies against Cryptosporidium and other resistant pathogens.
Investigation of HOCl’s killing rate, biofilm formation prevention, antimicrobial activity, and effects on fibroblast and keratinocyte migration. Demonstrated rapid microbial elimination (12 seconds) and dose-dependent favorable effects on wound healing.
Expert panel consensus on topical stabilized HOCl for wound care and scar management in dermatologic and plastic surgery procedures. Concluded HOCl may become “the future gold standard” for these applications.
Retrospective analysis of 1,249 venous leg ulcers in 897 patients treated with HOCl. All wounds achieved complete healing, with HOCl described as “perhaps the greatest advance in venous leg ulcer care.”
Eight-week safety study in mice consuming HOCl as drinking water. No systemic effects, no tissue changes, no adverse reactions. Concluded HOCl would be safe even if ingested.
Comprehensive safety review of in vitro toxicology, cytotoxicity, skin irritation, and eye irritation. Found HOCl caused no harm and recommended expanded use in medical care.
Landmark study identifying HOCl generation by human neutrophils as a key component of the innate immune response.
Investigation of how HOCl regulates neutrophil extracellular trap release and its role in immune function.
Expert panel consensus on topical stabilized HOCl for wound care and scar management in dermatologic and plastic surgery procedures. Concluded HOCl may become “the future gold standard” for these applications.
Expert panel consensus on topical stabilized HOCl for wound care and scar management in dermatologic and plastic surgery procedures. Concluded HOCl may become “the future gold standard” for these applications.
Comprehensive safety review of in vitro toxicology, cytotoxicity, skin irritation, and eye irritation. Found HOCl caused no harm and recommended expanded use in medical care.
Landmark study identifying HOCl generation by human neutrophils as a key component of the innate immune response.
Investigation of how HOCl regulates neutrophil extracellular trap release and its role in immune function.
View our complete bibliography of 130+ scientific references documenting HOCl’s safety, efficacy, and mechanisms of action.
Download Research Compendium
For additional information, partnership inquiries, or to request access to our comprehensive bibliography of 130+ scientific and clinical references documenting hypochlorous acid (HOCl)’s safety, efficacy, and mechanisms of action, please contact our team directly.
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"Hypochlorous acid (HOCl) is the form of free available chlorine that has the highest bactericidal activity against a broad range of microorganisms."
"Hypochlorite-based products dissolve in water to create a dilute aqueous chlorine solution in which undissociated hypochlorous acid (HOCl) is active as the antimicrobial compound."
"The Committee judged that hypochlorous acid water of 35 ppm or higher was effective, which showed a more than 99.9% reduction of viral titer."
"In the last 15 years, more advanced hypochlorous acid (HOCl) solutions have emerged as safe and viable wound-cleansing agents and infection treatment adjunct therapies."
"It comprises many of the desired effects of the ideal disinfectant: easy to use, inexpensive, has a good safety profile, and can be used to disinfect large areas quickly with broad bactericidal and virucidal effects."
